The many villains from the Multiverse have been bested by the Freedom Five, Dark Watch, the Prime Wardens, or even heroes not from a particular team. Many of those villains are prideful and would not deign to work with others, as their ambitions would not align. However, some of them have seen the value of cooperating towards a common goal, and those villains have joined forces, even at cross purposes, to defeat the heroes who have harried them for so long. Villains of the Multiverse introduces a collection of ten super-powered villains, as well as four new environments for use with Sentinels of the Multiverse card game.