To win, each Villain must complete a unique story-based objective. To win as Loki, players must gain and spend ten mischief, which is primarily gained via multiverse personalities played by Loki to other Villains Domains. M.O.D.O.K. needs to maintain A.I.M.s loyalty and activate the Cosmic Cube. Finally, Madame Masque must vanquish eight heroes specifically to settle her vendetta. Shell need to balance vanquishing heroes to satisfy her vendetta or vanquishing them for a contractone of the only ways in the game she can gain power. Marvel Villainous: Mischief & Malice can be combined with Marvel Villainous: Infinite Power to support up to a four-player game.